A significant portion of the world's online pharmacies are operating illegally, posing serious health risks to consumers, according to the U.S. Trade Representative's 2024 "Notorious Markets" report. The report highlights a pervasive issue of counterfeit and pirated products, detailing various illicit activities and naming numerous online retailers, especially in Asia.

The report's findings paint a concerning picture. Nearly all (96%) of the analyzed online pharmacies are believed to be operating outside of legal frameworks. These retailers frequently lack proper licenses, sell medications without prescriptions, and omit vital safety warnings. Their websites often mimic legitimate platforms, falsely claiming FDA approval, further complicating consumer discernment.

The FDA and DEA have issued warnings regarding the risks associated with purchasing prescriptions from these unauthorized online sources. A survey from the Alliance for Safe Online Pharmacies revealed that nearly one in four Americans who used online pharmacies encountered substandard, counterfeit, or harmful medications. This underlines the serious threat to public health.

Critically, the report highlights a recent case involving a network of illegal drug sellers operating across the U.S., the Dominican Republic, and India. This network allegedly packaged synthetic opioids disguised as common prescription drugs, leading to at least nine fatalities from narcotics poisoning. These findings underscore the dangerous reality of counterfeit pharmaceuticals.

Beyond the immediate health risks, the report points out that illicit products are often produced in unsanitary conditions, increasing concerns about potential contaminants and allergic reactions. The report notes the prevalence of imported ingredients, including fentanyl from China, as another troubling factor.

While progress has been made in combating counterfeiting, particularly in Vietnam and other locations, challenges persist. Cyberlockers used to circumvent piracy restrictions and "bulletproof" internet service providers (ISPs) that facilitate pirate site access continue to pose a hurdle. Platforms like Baidu Wangpan, Pinduoduo, and Douyin Mall, while demonstrating some effort in curtailing counterfeiting, still host significant amounts of illicit goods. While Shopee shows a relatively better record, the report cites persistent issues with IndiaMART.

This report highlights the pervasiveness of online counterfeiting, spanning various sectors from pharmaceuticals to pirated content and counterfeit consumer goods, even extending to physical locations. Examples include markets in Turkey, bazaars in the UAE, and while the MBK Center in Bangkok has been making strides, counterfeit products still circulate. The investigation emphasizes the global nature of this problem, requiring international cooperation to effectively address it.