Israeli strikes across Gaza have reportedly killed at least 22 Palestinians, according to Palestinian medical sources, as the US and other mediators intensify efforts to broker a ceasefire before President Biden leaves office. The latest violence comes amid intense diplomatic efforts to end the conflict, which began on October 7th, 2023, following Hamas's attack on southern Israel.

Multiple airstrikes targeted residential areas, including a multi-story building in Sheikh Radwan and areas in Zeitoun and Deir al-Balah, resulting in significant casualties. Palestinian medics reported numerous fatalities, including women and children.

Meanwhile, international efforts to secure a ceasefire are underway, driven by the United States, Qatar, and Egypt. A source close to the negotiations characterized the current attempt as the most serious yet. The Biden administration is pushing for a final agreement before the end of the week, while many in the region see President-elect Trump's inauguration as a potential deadline.

However, despite heightened diplomatic activity, negotiations face significant obstacles. Hamas has reportedly demanded Israel's complete withdrawal from Gaza and an end to the war as a condition for releasing hostages. Israel, meanwhile, has accused Hamas of obstructing the peace process.

The escalating violence has created a humanitarian crisis in Gaza. Hundreds of thousands of Palestinians are displaced and facing severe shortages of food and medicine. Furthermore, recent heavy rains and flooding have further complicated the situation for those sheltering in damaged tents, leaving families struggling to survive without basic necessities. International humanitarian agencies are raising concerns about the dire conditions in the region.

The conflict has claimed the lives of over 1,200 Israelis and upwards of 46,000 Palestinians. The ongoing fighting demonstrates the deep-seated complexities and challenges in achieving a lasting resolution.